منابع مشابه
An Immunohistochemical Study of Cyclin D1 Expression in Astrocytic Tumors and its Correlation with Tumor Grade
Background & Objective: Glioblastoma-multiforme is the high grade form of astrocytic tumors with a short survival time, which are the most common type of brain tumors. Therefore, finding new therapeutic options is essential. Cyclin D1 is expressed in some human malignancies and can be a potential target for therapeutic intervention. The aim of the present study was to determine...
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34 One of the most important functions of astrocytes is removal of glutamate released 35 during synaptic transmission. Surprisingly, the mechanisms by which astrocyte 36 glutamate uptake is acutely modulated remain to be clarified. Astrocytes express 37 metabotropic glutamate and other G protein-coupled receptors (GPCRs) which are 38 activated during neuronal activity. Here we test the hypothes...
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Nestin is an intermediate filament (IF) protein. These intermediate filament proteins are expressed mostly in neural stem cells [1-3]. Nestin is also expressed by many other stem cells and it is considered a primitive marker [4-7] . Upon differentiation, Nestin becomes down-regulated and is replaced by tissue-specific intermediate filament proteins [8]. During neuroand gliogenesis, Nestin is re...
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Rhabdoid glioblastoma (RGBM) is rare, but the most malignant among astrocytic tumors. Accumulating evidence indicates its highly aggressive nature and distinct histopathological features. Here, we report a new case of RGBM and review previously reported cases of astrocytic tumors with rhabdoid components. We describe a 58-year-old man who presented with aphasia and right-sided weakness. Magneti...
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Rhabdoid glioblastoma (RGBM) is rare, but the most malignant among astrocytic tumors. Accumulating evidence indicates its highly aggressive nature and distinct histopathological features. Here, we report a new case of RGBM and review previously reported cases of astrocytic tumors with rhabdoid components. We describe a 58-year-old man who presented with aphasia and right-sided weakness. Magneti...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2016
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn.2016.77